CBD Oil For Trigeminal Neuralgia


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Does the pain brought by trigeminal neuralgia bother you? Perhaps you want to consider using CBD oil to manage your symptoms and improve your quality of life. CBD can ease neuropathic pain through its interaction with the endocannabinoid system. Does it mean you can successfully treat trigeminal neuralgia with CBD oil? Let’s shed more light on the mechanism of action. Trigeminal Neuralgia (TN) is caused by damage or dysfunction in the trigeminal nerve, resulting in severe pain on the face.

Compare the Best CBD Oil for Trigeminal Neuralgia in 2022

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
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No other flavors

Approximately 300 drops total


Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
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No artificial flavoring or colors

No THC-free option

Made from 100% organic and natural ingredients


The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
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Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test


Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
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Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team


cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
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60-Day Satisfaction Guarantee

Dropper is a bit shaky

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices


CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
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No other flavors

A bit pricey compared to competitors

Approximately 100 drops total


This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
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Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes


A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
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Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee


Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

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How CBD May Help With Trigeminal Neuralgia

TN ( trigeminal neuralgia ) is a medical condition characterized by chronic pain from the trigeminal nerve , which carries sensation from the face to the brain (1) .

CBD’s activity in the ECS ( endocannabinoid system ) may explain how this non-psychoactive compound may help with chronic pain and conditions like trigeminal neuralgia .

The ECS is vital to the CNS ( central nervous system ) and plays a role in regulating pain and inflammation (2) .

The ECS consists of cannabinoid receptors type 1 and 2 (CB1 and CB2), endocannabinoids, and enzymes.

Cannabinoids , like CBD and THC , may exert their antinociceptive properties through complex mechanisms involving effects on the CNS, spinal cord , and peripheral sensory nerves (3) .

Antinociceptive agents are compounds that can diminish pain without adverse effects on consciousness.

CB1 receptors play a key role in pain sensation (4) . Meanwhile, recent studies suggest that CB2 receptors may be involved in the antihyperalgesic activity of cannabinoids in acute, chronic, and neuropathic pain (5) .

Antihyperalgesic activity refers to the ability of certain compounds to counteract hyperalgesia or extreme sensitivity to pain.

Although CBD has a low binding affinity for both cannabinoid receptors , it may antagonize them in the presence of THC (6) .

The non-psychoactive compound may also regulate pain perception (7) . Thus, CBD may help with painful conditions such as trigeminal neuralgia .

Opioids are medications for persistent or severe pain. Despite their high potential for abuse, these prescription drugs are used mostly as an adjunct to anticonvulsants (8) .

Opioids are also prevalent in patients with facial pain, including those who have TN (9 ) .

However, opioid abuse has become a national crisis in the United States, in which 90 Americans die by overdose each day (10) . For this reason, more studies are exploring the use of cannabis as a substitute for opioids (11 ) .

Cannabis refers to a group of plants, such as Cannabis sativa, Cannabis indica, and Cannabis ruderalis. These plants have more than 100 chemical components known as cannabinoids.

THC ( tetrahydrocannabinol ) and CBD ( cannabidiol ) are among the phytocannabinoids (plant-based cannabinoids) found in cannabis plants .

THC is the principal psychoactive compound of cannabis . The compound is responsible for the euphoric high users’ experience.

A study published in 2021 noted that, unlike opioids, cannabis has no reported deaths due to overdodse (12) .

Meanwhile, CBD is non-psychoactive. Some studies also suggest that CBD may antagonize at least some of the adverse effects of THC (13) .

The non-psychoactive compound has been of particular interest as a target for opioid use disorder (14) .

In a survey in California, about 80% of patients who used medical cannabis either as a substitute or in conjunction with opioid -based pain medication claimed that cannabis is more effective than opioids for pain (15) .

A study from the journal Neurology assessed the efficacy of medical cannabis in patients with trigeminal neuralgia ( 16) .

Of the 42 patients with TN, 81% reported improvements in their symptoms, while 50% said they reduced their opioid consumption with medical cannabis (17 ) .

The most efficacious dosage for the patients involved was a 1:1 ratio of THC to CBD (18) .

Although CBD may not be a standalone treatment for chronic pain , it is believed that using CBD as an adjunct therapy may provide pain relief , reduce the amount of opioid medication a patient is taking, and improve the overall quality of life (19) .

Benefits of Using CBD for Trigeminal Neuralgia

Cannabidiol has been shown to have anti-inflammatory and analgesic properties (20) . These potential health benefits may help individuals with trigeminal neuralgia .

TN is inflammation of the trigeminal nerve , a large three-part nerve in the head that provides sensation. It is a form of neuropathic pain associated with nerve lesions or nerve injuries.

It is believed that trigeminal nerve pain may be triggered by the contraction of blood vessels in the trigeminal nerve , damaging the trigeminal protective tissue (21) .

For individuals with TN, even mild stimulation of their faces, such as putting on makeup or brushing their teeth, may trigger an excruciating pain similar to an electric shock (22) .

A study from the European Journal of Pharmacology examined CBD’s efficacy in rat chronic inflammatory and neuropathic pain (23) .

The researchers administered 2.5-20 mg of CBD to neuropathic models and 20 mg of CBD to adjuvant-injected rats from days 7 to 14.

An adjuvant is an ingredient that may help create a more robust immune response in individuals receiving vaccines.

The findings indicated a potential for the therapeutic use of CBD in chronic painful states (24) .

It has been demonstrated that trigeminal neuralgia is common in patients with MS ( multiple sclerosis ), a disease that particularly affects the brain and spinal cord (25) .

Pain is a common symptom in multiple sclerosis , and about 75% of MS patients experience it (26) .

An elevated relative risk has also been associated with high blood pressure , particularly among women with trigeminal neuralgia (27) .

Preclinical studies showed that CBD may reduce blood pressure response to stress (28) .

These studies seem promising. However, they are either based on animal research or small clinical trials .

Still, the findings may be useful to researchers conducting further studies on CBD’s efficacy in painful conditions , like trigeminal neuralgia .

How to Take CBD for Trigeminal Neuralgia

Below are standard delivery methods by which CBD is taken into the body (29) :

  • Inhalation ( vape pens)
  • Ingestion ( edibles like gummies and capsules)
  • Sublingual or under the tongue ( tinctures , strips, tablets, and sprays)
  • Topical ( CBD creams , salves, lotions, and balms)

TN patients may initially experience mild attacks that can progress to more-frequent bouts of pain (30) .

Inhaling CBD using vape pens is the quickest way to benefit from the compound. CBD usually takes effect within two to 15 minutes via the inhalation route (31-32) . However, vaping may damage the lungs (33) .

Hence, talk with a healthcare professional experienced in cannabis use to determine which delivery route is best for trigeminal neuralgia or any health conditions .

CBD Dosage

The FDA ( Food and Drug Administration ) has not approved CBD as a treatment for trigeminal neuralgia . Hence, there is no standard CBD dosage for such a condition.

The general rule is to start with low doses . However, it is believed that mid-range doses between 10mg and 100mg of CBD daily may help with pain management (34) .

Still, it is best to talk with a healthcare professional with a background in cannabis use and dosing . They can advise you regarding the proper CBD dosage for trigeminal neuralgia .

How Long Does CBD Take to Help Trigeminal Neuralgia ?

How long it takes for cannabidiol to help with TN depends on several factors like the route of administration used, individual body weight, and CBD potency.

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If you choose to take CBD via the inhalation route, expect to feel CBD’s effect within two to 15 minutes (35) . Meanwhile, when taken sublingually, the effects of CBD take much longer, usually between 15 and 30 minutes (36) .

How Long Will CBD Help With Trigeminal Neuralgia ?

How long CBD will last after it takes effect depends on its half-life and bioavailability.

Half-life is the time needed for the concentration of a specific substance to decrease by 50% of its starting dose in the body. It is believed that 94% to 97% of a drug will have been eliminated following four to five half-lives (37) .

The half-life of CBD was reported between 1.4 and 10.9 hours after oromucosal spray and 31 hours following smoking (38) .

Meanwhile, bioavailability is the extent to which a particular drug becomes entirely available to its biological destination.

The bioavailability of CBD following smoking is 31% (39) . The bioavailability of cannabidiol when taken under the tongue is between 6% and 20% (40) .

Choosing the Best CBD Oil for Trigeminal Neuralgia

Most CBD companies are determined to provide high-quality CBD products like CBD oil for trigeminal neuralgia and overall wellness .

With many CBD brands promising the same thing, choosing the right product for you can be challenging.

Below are a few pertinent things to consider before buying any CBD product :

CBD Extracts

A full-spectrum CBD oil includes all the compounds of the cannabis plant , including CBD and other cannabinoids , essential oils, terpenes , and flavonoids.

A full-spectrum CBD provides the entourage effect, the theory wherein the biologically active compounds of cannabis work better together. Its THC concentration is also less than 0.3%.

Terpenes are aromatic compounds present in cannabis and many other plants. Flavonoids are plant chemicals with purported anti-inflammatory , antioxidant, and antiviral actions (41) .

A broad-spectrum CBD oil is almost the same as the full spectrum. However, it is nearly THC -free. Meanwhile, CBD isolates are made of pure CBD.


Check the ingredients to find out if there are any possible allergens or additives that may adversely affect you.

Generally, CBD products are infused with carrier oils, including MCT (medium-chain triglycerides) oil, coconut oil, and hempseed oil.

CBD Strength and Potency

The COA (certificate of analysis) is a document that indicates the amount of CBD, THC , and other ingredients in a CBD product .

The CBD company you choose must enlist the services of a third-party laboratory to check all products , ensuring objectivity and transparency.

Extraction Method

Carbon dioxide extraction , ethanol extraction , or solvent extraction with olive oil are preferred methods to create a safe CBD product (42) .

On the other hand, extraction techniques using hexane or butane may leave harmful residues.

Brand Reputation

Always purchase CBD products from a reputable store or dispensary authorized to sell CBD products .

Read customer feedback to get more insight about the manufacturer and its products.

The Potential Risks and Side Effects of Using CBD for Trigeminal Neuralgia

CBD is relatively safe and is well tolerated in humans and animals (43) . Still, the compound may induce risks and minor side effects , including (44) :

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness
  • Fatigue

The first-line treatment for trigeminal neuralgia is anticonvulsant medical therapy (45) . However, these drugs, primarily used to treat epileptic seizures, may interact with CBD (46) .

At high doses, CBD may inhibit the activity of cytochrome P450, a family of liver enzymes that metabolize about 60% of pharmaceutical drugs people consume (47) .

Antiepileptics or anticonvulsants use the cytochrome P450 enzyme system, which explains their possible interaction with CBD (48) .

Legality of CBD

The 2018 Farm Bill indicates that Cannabis sativa L. and other derivatives of cannabis with less than 0.3% THC on a dry weight basis are federally legal in the United States (49) .

In addition, some states like Colorado have passed laws allowing recreational and medical marijuana use. Still, these state laws do not change the fact that marijuana is listed as a Schedule I drug under federal law (50-51) .

Some states may even require a medical marijuana card to purchase cannabis products from authorized dispensaries . Therefore, make sure to research state legislations concerning cannabis use to avoid legal repercussions.

Product Frequently
Asked Questions

How can CBD help with trigeminal neuralgia?

There is no direct study suggesting that CBD can help with TN ( trigeminal neuralgia ).

However, CBD may be effective in different types of pain due to its analgesic properties (52) . The non-psychoactive compound may also help with several neurological disorders (53) .

TN is a rare neurological condition that causes chronic and severe facial pain (54) . A person with such a condition may feel burning sensations in the face.

As mentioned, CBD has pain-relieving effects (55) . These properties may help with painful conditions like trigeminal neuralgia .

What evidence or research exists to say that CBD helps with trigeminal neuralgia?

A 2019 study suggested that medical cannabis may be a valuable part of a comprehensive pain management plan for TN patients (56) . Researchers reported that the 1:1 ratio of THC to CBD is the most effective dosage among these patients.

Although CBD may not be a standalone treatment for chronic pain caused by various medical conditions like TN, the compound may provide pain relief to people and therefore contribute to their improved quality of life (57) .

Is there any evidence that CBD can make trigeminal neuralgia worse?

No evidence suggests that CBD can make trigeminal neuralgia worse. However, CBD may still induce risks and side effects like fatigue (58) .

Will CBD interact with any current medication I may be taking for trigeminal neuralgia?

CBD may interact with other medications like anticonvulsants , which are first-line treatments for TN (59-60) .

At high doses, CBD may inhibit the activity of cytochrome P450, a family of liver enzymes that metabolize about 60% of pharmaceutical drugs people consume (61) .

Antiepileptics or anticonvulsants use the cytochrome P450 enzyme system, which explains their possible interaction with CBD (62) .

Are there other treatments I should consider alongside CBD to help with trigeminal neuralgia?

Painkillers like paracetamol are ineffective in managing pain associated with TN. One type of pain relief medication prescribed to TN patients is an anticonvulsant (63) .

Muscle-relaxing agents may also be used to help with TN. However, their side effects include drowsiness, confusion, and nausea (64) .

Thus, ensure to talk with your doctor if you consider other treatments alongside CBD to help manage TN symptoms.

Can I fail a drug test if I use CBD for trigeminal neuralgia?

CBD does not cause euphoria (65) . Still, some CBD products have small amounts of THC that may build up in the body when taken regularly in a span of four to six days (66) .

An increased THC level in the bloodstream may result in a positive drug test.

What is the dosage for trigeminal neuralgia?

There is no standard CBD dosage for TN. However, doses between 10mg and 100mg may help with pain management (67) . TN is characterized by chronic pain (68) .

How should I use CBD oil for trigeminal neuralgia?

Inhaling CBD using vape pens usually takes effect within 2 to 15 minutes via the inhalation route (69) . However, extra caution is needed as vaping may damage the lungs (70) .

CBD Oil for Trigeminal Neuralgia: Is Cannabis a Viable Approach?

Neuropathic pain has many faces, one of which includes trigeminal neuralgia. This condition affects the nerves that transmit sensation from the face to the brain, causing severe discomfort comparable to an electric shock. The TN pain can be triggered by the slightest movement or touch anywhere on the face, commonly affecting the lips, gums, jaw, and cheeks.

People with trigeminal neuralgia usually suffer from flare-ups affecting one side of the face at a time. Although short-lived at the beginning, the episodes of burning sensation may become chronic, lasting for weeks or longer.

CBD has been mentioned by researchers as a potentially viable remedy for pain that is difficult to treat. Trigeminal neuralgia fits within this definition like a glove.

Today we’ll elaborate on the problem of TN pain and how to treat it with natural resources.

CBD Oil for Trigeminal Neuralgia: Highlights

  • Trigeminal Neuralgia (TN) develops as a result of the damage caused to the trigeminal nerve, causing severe pain on the face.
  • CBD’s interaction with the endocannabinoid system (ECS) may provide relief from neuropathic pain by mitigating the pain signals. According to a study published in Pharmacological Reviews, CBD strengthens nerve impulses in the ECS receptors, producing analgesic effects (1).
  • A review of studies concluded that topical CBD might be useful in reducing neuropathic pain and sensitivity to pain signals (hyperalgesia) (2).
  • Researchers have reported that hypertension (high blood pressure) increases the risk of trigeminal neuralgia. In a 2017 study, subjects who received CBD showed reduced resting blood pressure (3).
  • More clinical studies on humans are needed to support the preclinical findings of CBD’s benefits for people with trigeminal neuralgia.

Why People Are Turning to CBD for Trigeminal Neuralgia?

The dysfunction of the trigeminal nerve can have debilitating consequences for the sufferers. It causes severe pain on the face that occurs upon even the slightest movement, such as touching, scratching, or rubbing. The condition may also cause muscle spasms and burning sensations on top of the shock-like pain.

The treatment of trigeminal neuralgia usually involves anticonvulsant medications, antispasmodic agents, surgery, and other procedures involving the trigeminal nerve. Antiepileptic drugs, such as carbamazepine and gabapentin have been used with some success, although they lack efficacy and intolerability with prolonged use.

This is where CBD starts to shine.

Studies on CBD and Trigeminal Neuralgia

CBD is an acknowledged antiepileptic treatment. Its anticonvulsant and neuroprotective properties have been recently posted in a study from the journal Molecules. These actions might be useful in reducing muscle spasms in TN patients (4).

Although studies haven’t analyzed the efficacy of CBD on spasms caused by TN, there is evidence that CBD may have significant benefits for treating chronic pain caused by the condition.

One review has pointed to CBD as the potential reliever of hyperalgesia (pain sensitivity). The review mentioned that CBD can effectively block the pain pathway’s neural transmission. The authors also highlighted the nociceptive effects of cannabinoids, describing them as the potential therapeutic approach to the management of TN pain.

The painkilling and anti-hyperalgesia effects of CBD were supported by an animal study published in the Journal of Experimental Medicine. The study suggested that CBD reduced pain and inflammation caused by neuropathy.

Neuropathy stems from dysfunction or damage in the nerves that may trigger pain, tingling sensation, muscle weakness, and numbness.

On top of the above findings, the authors of the study added that CBD was able to curb hyperalgesia in mice models. There was a conclusion that CBD reduced persistent inflammation and neuropathic pain.

Another paper from the European Journal of Pharmacology demonstrated remarkable anti-inflammatory and immunomodulatory effects of CBD. Cannabidiol was administered to rats with induced sciatic nerve pain. The research team found that CBD treatment lowered inflammation and reduced hyperalgesia (5).

Experts hypothesize that trigeminal nerve pain can be caused by the contraction of blood vessels in the trigeminal nerve. This contraction damages the trigeminal protective tissue. Furthermore, researchers noticed that high blood pressure contributes to the development of trigeminal neuralgia (6).

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A 2017 preclinical study found that CBD has benefits for the cardiovascular system. The authors reported that healthy individuals (age 21–29) with hypertension caused by a stressful event showed lower blood pressure after taking CBD (7).

Since the majority of the studies on CBD and trigeminal neuralgia have been conducted on animal models and preclinical human samples, longitudinal clinical studies are needed to further prove CBD’s ability to treat the condition.

How Does CBD Oil Work for Trigeminal Neuralgia?

The benefits of CBD for trigeminal neuralgia are attributed to the human endocannabinoid system (ECS). The ECS is the major regulatory network engaged in maintaining homeostasis in the central nervous system, peripheral nervous system, immune system, and organs. The ECS contains receptors that are found throughout the body, including CB1, CB2, and glycine receptors.

Studies have found that the modulation of the ECS might promote the healthy functioning of biological processes, providing a wide range of therapeutic benefits.

For example, a study published in the Journal of Experimental Medicine found that modulating the ECS translates into therapeutic effects for pain management. The authors also mentioned that glycine receptors in the central nervous system are important targets for reducing neuropathic pain. According to the study, cannabinoids such as THC and CBD might enhance the activity of the glycine receptors, resulting in analgesic effects.

Glycine receptors are ion channels that control the transmission of pain signals from the nerve to the brain.

The study found that oral CBD products resulted in a binding glycine activity that lowered neuropathic pain and hyperalgesia in animal models.

The Pros and Cons of CBD Oil for Trigeminal Neuralgia

The Pros

  • Numerous studies have demonstrated the therapeutic potential of CBD in pain management thanks to its ability to modulate receptors in the ECS.
  • Researchers agree that CBD might strengthen nerve impulses and increase pain resistance.
  • Animal studies have found that oral CBD solutions might be useful in lowering one’s sensitivity to pain.
  • CBD can reduce blood pressure in healthy volunteers, indirectly reducing the risk of trigeminal neuralgia
  • Many international medical organizations agree that CBD is well-tolerated in humans and has a high safety profile.

The Cons

  • There is not enough clinical evidence to support CBD’s efficacy in treating trigeminal neuralgia
  • CBD has a few mild side effects, including dry mouth, reduced appetite, drowsiness, and CBD-induced drug interactions
  • According to one animal study, extremely high doses of CBD can cause liver toxicity. However, these results haven’t been confirmed on human subjects.

CBD vs. Alternative Treatments for Trigeminal Neuralgia

There are limited options when it comes to alternative treatments for trigeminal neuralgia. The alternative anticonvulsants, except for CBD, aren’t supported by scientific studies. Recently, acupuncture has been touted for its effectiveness in treating neuropathic pain. There are lots of reports from TN patients who claim to have successfully treated TN with acupuncture.

Acupuncture is part of traditional Chinese medicine that uses tiny needles to balance the energy flow within the body. Studies also mention acupuncture’s ability to support homeostasis in the ECS. However, direct studies are needed to find out how acupuncture affects cannabinoid receptors.

One study from Frontiers of Molecular Neuroscience has found that electroacupuncture increased receptor activity in the rat models of osteoarthritis, resulting in reduced pain. Electroacupuncture is performed by sending electric signals through the microneedles (8).

Weird as it may sound, CBD has similar effects on the body to electroacupuncture. One study has found that the modulation of adenosine receptors resulted in mitigated pain and lower inflammation in mice after they took CBD (9).

Vitamin B12 is another alternative for trigeminal neuralgia. Research shows that vitamin B12 has painkilling properties that may aid patients in managing neuropathic pain.

Several clinical studies have reported positive results after treating patients with methylcobalamin, a form of B12. These studies examined patients with different types of neuropathy, such as trigeminal neuralgia and diabetic neuropathy (10).

How to Take CBD Oil for Trigeminal Neuralgia?

CBD comes in different forms, concentrations, and formulas. It may be taken orally in the forms of capsules or gummies, or sublingually as oil drops. Some people vape CBD, while others use it topically for localized relief. The choice of the product boils down to your individual situation.

CBD oil is the most common format. It contains a hemp extract infused into an inert oil, such as MCT oil or olive oil. CBD oil comes with a dropper for easier and more accurate dosing. You just squeeze the preferred amount using the dropper, place a few drops under your tongue, and wait for up to 60 minutes until it absorbs through tiny capillaries in your mouth. The calming effects of CBD should be felt within 15–20 minutes.

If you don’t like the taste of CBD oil, capsules and edibles are a good alternative. CBD capsules are available in the form of soft gels, providing a fixed dose of CBD per serving. They are better suited for busy people who take their CBD on the go. Since the CBD needs to pass through the digestive system before absorbing into the bloodstream, capsules have a delayed onset, usually around 40–90 minutes depending on your metabolism and whether or not you’re taking CBD oil on an empty stomach.

Edibles work in a similar fashion, but they are made with fun flavors that make the whole experience more enjoyable. The most popular forms of CBD edibles are gummies and honey sticks.

If you’re looking for the most effective way to deliver CBD to your system, CBD vape pens will be your best bet. Vaporized CBD gets into the bloodstream through the lung tissue, producing its effects within minutes after inhalation. CBD vapes also offer the highest bioavailability of all consumption methods, ensuring that up to 56% of the ingested substance is absorbed.

Finally, you may try a topical formulation, such as CBD creams for localized relief. Topicals work best for flare-ups because they address inflammation by interacting with the CB2 receptors in the skin’s endocannabinoid system. The absorption rate and duration of CBD topicals vary between products; you may need to reapply the dose after a few hours for consistent results.

Dosage of CBD Oil for Trigeminal Neuralgia

There are not enough clinical trials to determine the effective CBD dosage for specific health conditions.

According to a study published in the British Journal of Pharmacology, a low dose may vary from less than 1 to 50 milligrams per one kilogram per day. Everybody is different, and factors like your age, gender, metabolism, weight, overall health, and prior experience with CBD will affect your optimal dosage range.

It will take some experimentation until you find out what works for you. It is recommended to start with a low dose, say, 10 mg of CBD once or twice daily for one week — and observe the results. If you don’t feel any pain relief after that time, add another 10 mg to the dosage and continue for another week. Once you’ve found an effective dose, you can stick to it — people don’t build a tolerance to CBD.

If you’re thinking about adding CBD oil to your trigeminal neuralgia treatment, consult a holistic doctor experienced in CBD and cannabis therapies in general. Doing so will help you determine the right dosage range for your condition on top of avoiding potential negative CBD-induced drug interactions.

Summarizing the use of CBD for Trigeminal Neuralgia

Studies support CBD’s therapeutic effects in a range of painful conditions, including neuropathic pain. CBD modulates the activity of the cannabinoid receptors in the ECS, mitigating pain signals and reducing inflammation throughout the body. Moreover, CBD has been found to reduce blood pressure when administered under stressful conditions. All these effects can have a positive impact on the symptoms of trigeminal neuralgia. CBD is also an acknowledged anticonvulsant and neuroprotectant, so it can prevent further damage to the trigeminal nerve.

More direct clinical trials are needed to prove CBD’s efficacy specifically in alleviating TN pain. However, current findings, as well as reports from patients, are very encouraging.

Do you take CBD for trigeminal nerve pain? What products work best for you? Share your thoughts in the comment section!


  1. Pacher, Pál et al. “The endocannabinoid system as an emerging target of pharmacotherapy.” Pharmacological reviews vol. 58,3 (2006): 389-462. doi:10.1124/pr.58.3.2
  2. Liang, Ying-Ching et al. “Therapeutic potential of cannabinoids in trigeminal neuralgia.” Current drug targets. CNS and neurological disorders vol. 3,6 (2004): 507-14. doi:10.2174/1568007043336833
  3. Turner, C L et al. “Measurement of pulse pressure profiles in patients with trigeminal neuralgia.” Journal of neurology, neurosurgery, and psychiatry vol. 74,4 (2003): 533-5. doi:10.1136/jnnp.74.4.533
  4. The U.S. Food and Drug Administration. The FDA Approves First Drug Comprised of Cannabidiol.
  5. Costa, Barbara et al. “The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.” European journal of pharmacology vol. 556,1-3 (2007): 75-83. doi:10.1016/j.ejphar.2006.11.006
  6. Trigeminal Neuralgia Overview.
  7. Jadoon, Khalid A et al. “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.” JCI insight vol. 2,12 e93760. 15 Jun. 2017, doi:10.1172/jci.insight.93760
  8. Yuan, Xiao-Cui et al. “Electroacupuncture Potentiates Cannabinoid Receptor-Mediated Descending Inhibitory Control in a Mouse Model of Knee Osteoarthritis.” Frontiers in molecular neuroscience vol. 11 112. 6 Apr. 2018, doi:10.3389/fnmol.2018.00112
  9. Russo, Ethan B. “Cannabinoids in the management of difficult to treat pain.” Therapeutics and clinical risk management vol. 4,1 (2008): 245-59. doi:10.2147/term.s1928
  10. Zhang, Ming et al. “Methylcobalamin: a potential vitamin of pain killer.” Neural plasticity vol. 2013 (2013): 424651. doi:10.1155/2013/424651
Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

CBD Oil for Trigeminal Neuralgia – August 2022

Trigeminal neuralgia (TN) is a form of neuropathic pain condition caused by dysfunction in the trigeminal nerve, or fifth cranial nerve . The nerve is responsible for carrying sensation signals from the face to the brain.

TN pain has been reported to be so severe that it has been called the “ suicide disease ” (5) .

Slight stimulations on the face, such as touching, brushing, and washing may cause severe facial pain . TN may also cause muscle spasms, feelings of electric shock , and burning sensation .

TN treatments include anticonvulsant agents, antispasmodic agents, and potentially invasive surgical procedures.

Antiepileptic medications, such as gabapentin and carbamazepine, have been used to treat TN (6) . However, the lack of intolerability and efficacy has been observed among these medications after prolonged use (7) .

CBD is a proven antiepileptic treatment (8) . A recent study posted in Molecules mentioned evidence of CBD ’s anticonvulsant and neuroprotective properties. These actions might help reduce spasms and nerve pain (9) .

Studies have not investigated CBD ’s efficacy on spasms caused by TN. However, CBD might have therapeutic benefits for treating chronic pain caused by TN (10) .

A review shared that cannabinoids , such as CBD , might help alleviate neuropathic pain and hyperalgesia (pain sensitivity). The review mentioned that there is evidence that cannabinoids might block the pain pathway ’s neural transmission (11) .

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The authors added that the nociceptive effects produced by cannabinoids might be a potential therapeutic approach to the management of trigeminal neuralgia (12) .

The analgesic and anti-hyperalgesic effects of CBD were supported by an animal study published in the Journal of Experimental Medicine (13) .

The study mentioned that CBD possesses therapeutic benefits that might reduce pain and inflammation that causes neuropathy (14) .

Neuropathy is dysfunction or damage in the nerves that may cause pain, tingling and burning sensations , numbness, or muscle weakness.

Moreover, the authors added that CBD was able to mitigate hyperalgesia in mice models. The study concluded that CBD reduced persistent inflammation and neuropathic pain (15) .

Another study shared in the European Journal of Pharmacology demonstrated that CBD may possess potent anti-inflammatory and immunomodulatory effects (16) .

In the study, oral CBD was administered on rat models with induced sciatic nerve compression. Researchers found that CBD treatment reduced hyperalgesia and reduced inflammation (17) .

According to experts, trigeminal nerve pain can be caused by a blood vessel pressing on the trigeminal nerve . This compression causes damage to the trigeminal’s protective coating (myelin sheath) (18) . In severe cases, this vessel may need to be surgically separated from the trigeminal nerve.

Moreover, researchers observed that high blood pressure increases the risk for TN (19) .

A preclinical study acknowledged that CBD has cardiovascular benefits (20) . The authors mentioned that healthy volunteers (age 21-29) whose hypertension is triggered by stress displayed a lower resting blood pressure after taking CBD .

Clinical studies without limitations are needed to confirm CBD ’s potential ability to reduce blood pressure in older individuals.

Most of the studies mentioned have shown results using animals as test subjects. More clinical studies are needed to prove CBD ’s efficacy in alleviating nerve pain .

How CBD Oil Works to Help With Trigeminal Neuralgia

The endocannabinoid system (ECS) is essential in maintaining homeostasis in the central nervous system , peripheral nervous system , immune system, and organs.

The ECS is composed of receptors that are spread across the human body. These receptors include the cannabinoid receptors (CB1 and CB2) and glycine receptor (GLyR) (21) .

Studies acknowledged that modulating the receptors in the ECS might influence bodily functions, resulting in several therapeutic benefits (22) .

Modulatory effects can be triggered or stimulated by cannabinoids , such as cannabidiol ( CBD) , tetrahydrocannabinol ( THC ), cannabichromene (CBC), cannabinol (CBN), and cannabigerol (CBG) (23) .

A study posted by the Journal of Experimental Medicine suggested that modulating the ECS might have therapeutic effects in pain management (24) .

Moreover, the authors mentioned that glycine receptors in the central nervous system are an essential target for alleviating neuropathic pain (25) .

The authors added that cannabinoids , such as THC and CBD , might strengthen nerve impulses in the glycine receptors, resulting in analgesic potency (26) .

Glycine receptors are ion channels that are responsible for neurotransmission.

The study found that oral CBD treatment provided a binding glycine activity that reduced hyperalgesia and neuropathic pain in mice models.

The Pros and Cons of CBD Oil for Trigeminal Neuralgia

The Pros
  • Studies demonstrated that CBD might have therapeutic effects in pain management by modulating receptors in the ECS (27) .
  • Researchers acknowledged that CBD might strengthen nerve impulses in the ECS receptors, resulting in analgesic potency (28) .
  • Animal studies have shown that oral CBD treatment might be useful in alleviating neuropathic pain and hyperalgesia (pain sensitivity) (29) .
  • Studies have shown that CBD might reduce blood pressure . High blood pressure might increase the risk for TN (30) .
  • Researchers acknowledge that CBD is well-tolerated and has an excellent safety profile (31) .
The Cons
  • There are not enough clinical studies that support CBD ’s efficacy in treating trigeminal neuralgia .
  • Studies mentioned that CBD might cause adverse effects, such as dry mouth, diarrhea, drowsiness, loss of appetite, and CBD -induced drug interactions (32) .
  • An animal study has shown that CBD might cause hepatotoxicity (liver damage) when taken in extremely high doses. This hypothesis is supported by the US Food and Drug Administration (FDA) (33) .

How CBD Oil Compares to Alternative Treatments for Trigeminal Neuralgia

There are not many alternative treatment options for painful conditions, like TN. The efficacy of alternative anticonvulsants for treating TN is currently not supported by scientific studies.

A popular alternative treatment for TN is acupuncture. A review mentioned that a 66-year woman suffering from TN believed that she was successfully treated by acupuncture (34) .

Acupuncture is a Chinese tradition that uses microneedles to balance the energy in the body.

Researchers mention that acupuncture may help maintain homeostasis in the ECS and must be investigated. So far, no direct studies have been made on how acupuncture might trigger the cannabinoid receptors (35) .

A study published in Frontiers of Molecular Neuroscience has found that electroacupuncture on osteoarthritis rats was able to increase receptor activity, resulting in reduced chronic pain (36) .

Electroacupuncture is conducted by sending electrical signals through acupuncture needles.

CBD has somewhat similar characteristics to electroacupuncture. A study discussed that CBD ’s modulation of adenosine receptors resulted in reduced pain and inflammation in rheumatoid arthritis mice (37) .

Another alternative treatment for TN is vitamin B12. Studies have shown that vitamin B12 has analgesic properties that might be useful for treating neuropathic pain (38) .

A review from Neural Plasticity cited clinical studies that produced positive results from neuropathic patients following treatments of methylcobalamin (MeCbl), a form of B12. These clinical studies included patients with neuropathic health conditions, such as TN and diabetic neuropathy (39) .

Clinical studies have yet to test CBD ’s efficacy on TN and diabetic neuropathy. However, a study acknowledged that CBD might also possess therapeutic benefits for neuropathic conditions.

CBD ’s modulation of glycine receptors resulted in alleviating chronic pain and hyperalgesia in mice models (40) .

How to Choose the Best CBD Oil for Trigeminal Neuralgia

Full-spectrum CBD oil carries all the major cannabinoids found in hemp plants, such as CBD , CBG, CBC, and 0.3% THC .

Full-spectrum CBD is recommended for treating neuropathic pain . A study posted in Therapeutics and Clinical Risk Management acknowledged the analgesic effects of other cannabinoids present in hemp (41) .

Broad-spectrum CBD contains the same cannabinoids in full-spectrum without THC . Broad-spectrum is recommended for individuals who do not want traces of THC in their system.

Full-spectrum and broad-spectrum types provide individuals with the “entourage effect.” The entourage effect means that all the cannabinoids are working in synergy.

Individuals who cannot tolerate other cannabinoids may opt for CBD isolate. This concentration contains 90% CBD .

Additional tips to consider before buying CBD :

  • Customers may check for cannabinoid concentration in the product by referring to the certificate of analysis (COA).
  • Checking testimonials and reviews from other customers is helpful.
  • Consulting with a neurologist before taking CBD is important.

CBD Dosage for Trigeminal Neuralgia

More clinical trials are crucial in determining the correct CBD dose for health conditions.

The British Journal of Pharmacology published a study that recommended a low dose of less than 1 to 50 milligrams kilograms per day (

Individuals may increase their dose once their bodies get used to having CBD in their system.

Moreover, a clinical study published by the Brazilian Journal of Psychiatry mentioned that a dose-response curve was observed with CBD (43) .

The authors explained that 300mg pure CBD treatment produced positive results, while 150mg and 600mg did not produce any changes.

Also, a high dosage of CBD is not recommended. A study released by Molecules observed that extremely high doses of CBD caused hepatotoxicity in rat models (44) .

How to Take CBD Oil for Trigeminal Neuralgia

CBD oil may be taken orally in forms of capsules, softgels, and gummies. Individuals may also take CBD capsules , gummies, and other edibles with a glass of water.

A study observed that CBD remained in the system three to four hours after oral intake (45) .

Individuals who want a higher potency of CBD may opt for sublingual administration. CBD tinctures may be taken by using an applicator to drop CBD under the tongue.

More studies are needed to determine absorption speed and plasma concentrations for sublingual delivery.

The half-life of sublingual CBD administration has been observed to be dose-dependent. Nevertheless, researchers observed that plasma concentrations are faster when individuals are in a fasted state (empty stomach) (46) .

CBD tinctures may have an earthy taste due to the presence of terpenes. Terpenes are aromatic compounds found in the plants.

Some individuals may want the fastest method for pain relief . Thus, CBD vape pens and cartridges may be recommended.

Studies have shown that the lungs can be very efficient in delivering CBD into the bloodstream (47) . The authors explained that inhaling CBD through vaporization could deliver plasma concentrations to the body in less than 10 minutes.

However, another study reported that vaping might cause side effects , such as chest pain, shortness of breath, allergic reactions, and chemical irritation (48) .

Are CBD Oil and Medical Marijuana the Same?

Some individuals may mistake CBD for medical marijuana . However, these compounds differ in cultivation and concentration.

Medical marijuana or medical cannabis can come from several cannabis strains. The cannabis plant is harvested for its flowers and leaves, after which they are cured and dried for consumption.

CBD is usually extracted from Cannabis sativa, particularly hemp, using CO2 extraction, solvent extraction, or steam distillation.

The extraction method creates a more concentrated version of hemp. The cannabinoids are manufactured into carrier oils, capsules, edibles, vape juice, and other products.

CBD and medical marijuana also differ in terms of THC content.

CBD contains only 0.3% THC or less, making it legal in all 50 US states and territories (49) . Meanwhile, some dispensaries sell cannabis products that may contain up to 25-28% THC (50) .

Recreational and medical use of marijuana is illegal in the US, except for 11 states. These states may require consumers to procure a medical marijuana card (51) .

Although CBD products are legal, the CBD market remains highly unregulated.

Individuals are advised to always look for the certificate of analysis (COA) before buying the product. The COA is a third-party lab test result from ISO-certified laboratories.

These labs test for cannabinoid concentration and harmful chemicals, such as heavy metals, pesticides, and other contaminants.

The COA allows consumers to know that the product is high-quality and safe for humans or pets.


Studies have shown that CBD might be useful in alleviating neuropathic pain and hyperalgesia . This mechanism is due to CBD’s ability to block neural transmission in the pain receptors (52) .

Researchers also acknowledged that CBD might produce analgesic potency by strengthening nerve impulses in glycine receptors (53) .

Moreover, studies have shown that CBD might indirectly reduce TN pain by lowering blood pressure (54) .

More direct studies are needed to prove CBD ’s efficacy in alleviating neuropathic pain .

However, researchers mention that CBD ’s therapeutic potentials showed promise in improving the quality of life of individuals with TN (55) .

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