Heavy Pot Smoking Linked With Stunted Growth
— Study adds to evidence for developmental abnormalities with teen marijuana use
by Jeff Minerd, Contributing Writer, MedPage Today May 20, 2015
This article is a collaboration between MedPage Today and:
Boys who smoked marijuana heavily were significantly smaller than their peers by the end of their adolescent growth phase, according to a study conducted in Pakistan.
Study participants who were described as “marijuana addicts” during boyhood were on average 4.6 inches shorter and 4 kg lighter at age 20 than nonsmokers, reported lead investigator Syed Shakeel Raza Rizvi, PhD, and colleagues at the PMAS-Arid Agriculture University Rawalpindi, in a presentation at the European Congress of Endocrinology in Dublin.
The investigators compared height; weight; and levels of luteinizing hormone, testosterone, growth hormone, and cortisol in 220 marijuana-addicted and 217 nonpot-smoking boys.
Plasma concentrations of luteinizing hormone, testosterone, and cortisol were significantly higher in the marijuana addicted boys, but levels of growth hormone were significantly lower.
Chronic pot smoking may trigger a stress response that stimulates the onset of puberty but lowers growth hormone levels, the researchers suggested, on the basis of a separate set of laboratory experiments.
To determine the acute effect of smoking marijuana on cortisol levels, the researchers measured salivary cortisol in 10 “drug addict volunteers” of unstated age before, during, and after smoking a 0.25 g marijuana cigarette. “Acute administration of marijuana induced significant increases in the salivary concentrations of cortisol,” the researchers reported.
“The mechanism underlying the stimulation of reproductive function by marijuana in pubertal boys needs to be examined in detail. Furthermore, the suppressive effect of cortisol on growth directly through inhibition of growth at the cellular level by depletion of nutrients or indirectly through inhibition of growth hormone secretion needs to be further studied,” Rizvi said via email to MedPage Today.
“In addition, it is to be ascertained whether cortisol itself or some other factor like nutritional status is attributable to decline in growth rate in pubertal marijuana addicted boys. We are examining these aspects currently,” Rizvi said.
In the U.S., marijuana is the most popular drug among young people, with 11.7% of 8 th graders and 35.1% of 12 th graders reporting having used it within the past year, according to a 2014 survey from the National Institute on Drug Abuse (NIDA).
More than 6% of 8th graders and 21% of 12th graders reported using marijuana within the past month, the survey found, and about 1% and 6% of 8th and 12th graders, respectively, said they used the drug daily.
No funding sources were reported for this study.
Dr. Rizvi reported no relevant financial relationships with industry.
European Congress of Endocrinology
Proceedings of the National Academy of Sciences
- Help Center
- Site Map
- Do Not Sell My Personal Information
- Advertise with us
- Accessibility Statement
The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider.
© 2020 MedPage Today, LLC. All rights reserved. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission.
Website Accessibility Statement (Last revised October 2020)
MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. Accessibility improvements made to our sites are guided by the Web Content Accessibility Guidelines (WCAG), Level AA. Across MedPage Today and its businesses, digital accessibility is a core priority for us throughout our design and development phases. We strive to make all of our content accessible to all users and continually work to improve various features of our sites. Such improvements to our sites include the addition of alt-text, navigation by keyboard and screen reader technology, closed captioning, color contrast and zoom features, as well as an accessibility statement on each site with contact information, so that users can alert us to any difficulties they have accessing our content.
MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our users and subscribers. In order to have the best experience on our sites, we recommend that users utilize the latest available versions of web browsers and assistive technology. We also rely on our community to tell us when they experience an issue with any of our sites, and we give consideration to all feedback that is provided to us.
Study adds to evidence for developmental abnormalities with teen marijuana use