Possible Link Between Marijuana Use, Tinnitus
— Study added to conflicting information on the issue
by Charles Bankhead, Senior Editor, MedPage Today September 16, 2019
NEW ORLEANS — Self-reported monthly or more frequent marijuana use had a significant association with tinnitus, according to a retrospective analysis of a national database.
Marijuana users were almost 20 times more likely to report having tinnitus within the past month as compared with nonusers. An extensive multivariable analysis confirmed marijuana use at least once a month as an independent predictor of tinnitus, as reported here at the American Academy of Otolaryngology-Head and Neck Surgery Foundation meeting.
“The findings do not suggest marijuana alleviates tinnitus,” said Z. Jason Qian, MD, of Stanford University in California. “In fact, the findings suggest that marijuana use may be associated with prevalent tinnitus, but no dose response was observed. The study is in line with animal studies that suggest cannabinoids may increase tinnitus.”
Research into the relationship between tinnitus and marijuana use has produced mixed results. A preclinical study conducted almost a decade ago suggested a potential role for marijuana in treating tinnitus. Proponents of medical marijuana for treating tinnitus have cited the study in making their case. A case report of a patient with longstanding idiopathic intracranial hypertension documented resolution of symptoms, including tinnitus, following treatment with the synthetic cannabis compound dronabinol.
On the other hand, a laboratory study suggested that cannabinoid receptor agonists exacerbated a preclinical model of tinnitus. A just-published literature review found limited support for therapeutic effects of cannabis in otolaryngology, none involving tinnitus. Authors of another recent review came to a similar conclusion.
Seeking more insight into the relationship between marijuana use and tinnitus, Qian and colleagues analyzed data from the 2011-2012 National Health and Nutrition Evaluation Survey (NHANES). They identified 1,582 adults who had audiometric testing and who completed questions that elicited information about hearing, drug use, current health status, and medical history.
Specifically, participants were asked whether they had symptoms of tinnitus lasting 5 minutes or longer within the previous 12 months and whether they had smoked marijuana one or more times a month for the past 12 months. Responses showed that 499 participants met the tinnitus criteria and 118 met the marijuana use criteria.
Qian and co-author Jennifer Alyono, MD, reported having no relevant relationships with industry.
American Academy of Otolaryngology-Head and Neck Surgery Foundation
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Study added to conflicting information on the issue