white house genetics

White House

Glimpse into the White House Cluster

The New York Times had geneticists sequence SARS-CoV-2 samples from two journalists who contracted the virus while covering the White House.

Survey of Scientists Finds Biden Support

A Nature survey finds a high level of support among scientists for former Vice President Joe Biden in the upcoming US election.

Spinning an FDA “Cocoon”

The New York Times reports on how the US Food and Drug Administration has attempted to gird against pressure from the White House.

“Dangerous” Proposal

The Washington Post reports that a herd immunity proposal has found a receptive audience at the White House to the dismay of most scientists.

“Colossal Failure”

A former Centers for Disease Control and Prevention director calls on the current director, Robert Redfield, to address the agency’s pandemic response shortcomings, USA Today reports.

Stricter Criteria Adopted

The Washington Post reports that the White House has approved new, stricter guidelines for seeking emergency authorization for a coronavirus vaccine.

Bright Leaves NIH Post

Rick Bright, the former BARDA head, has left his new post at NIH, saying he’s been “sidelined” there, NPR reports.

And Guidelines Blocked

According to the New York Times, the White House is preventing the release of stricter guidelines for the emergency authorization of a coronavirus vaccine.

Urged to Release Criteria

BIO has asked the Department of Health and Human Services to publish the criteria it developed for the emergency authorization of a coronavirus vaccine, the New York Times reports.

Quick Tests to Be Given Out

About 150 million rapid coronavirus tests purchased by the US federal government are to be distributed to nursing homes, colleges, and the states, according to the New York Times.

News and reporting on White House from GenomeWeb Genetics & Genomics.

Fred Hutch researchers uncover new genetic details of White House COVID-19 outbreak

by Lisa Stiffler on November 2, 2020 at 7:00 pm November 3, 2020 at 5:06 pm

Since it was revealed in early October, details about President Trump’s COVID-19 infection have been in short supply, including the likely source of his exposure and when he was tested.

New research from the Fred Hutchinson Cancer Research Center in Seattle gives a glimpse into the spread of the disease among America’s first family and White House staff and guests.

Two journalists who directly interacted with White House officials at the end of September — but were not in each other’s company — contracted variations of the virus that were “highly genetically similar.” The genetic code from the SARS-CoV-2, the virus that causes COVID, that infected the journalists contained five unique mutations and were distinct from the genomes of more than 160,000 publicly available virus sequences.

Our research group at @fredhutch, @UWMedicine and @BrotmanBaty has sequenced the viral genomes of two SARS-CoV-2 infections that were connected to the White House #COVID19 outbreak. The @nytimes reports here: 1/16

The scientists said this particular lineage of the virus was first documented in the U.S. in April or May, but its exact spread from there was unclear.

Shortly after Trump was infected, Anthony S. Fauci — the nation’s top infectious-disease expert — said that the White House had been the site of a so-called super spreader event when it hosted a Rose Garden reception for Judge Amy Coney Barrett, now a member of the U.S. Supreme Court. Photos show that many in attendance did not wear masks. At least 50 COVID-19 cases have been connected to an outbreak associated with the White House, according to the researchers.

Trump Administration officials at the time of the outbreak made little effort to do contact tracing to potentially help contain the spread — a decision that drew criticism from some health experts.

When it comes to the source of the White House infections, “it’s sort of an unknowable question, where it entered the environment,” said White House deputy press secretary Brian Morgenstern, in a press conference on Oct. 7.

The Fred Hutch-led research calls that assertion into question. While it’s too late to use the information to limit spread from the initial event, genomic sequencing could provide additional insights into the path of transmission if more samples were tested. It could also help build a more complete picture of the outbreak’s spread by analyzing infections that occur weeks or months following the White House event.

Researchers at the Fred Hutchinson Cancer Research Center have created a family tree for SARS-CoV-2, the virus that causes COVID-19, and identified the form associated with the White House outbreak. (Fred Hutch Image)

“We’ve seen repeatedly with COVID-19 that the absence of scientific statements provides shelter for speculation and even conspiracy theories to grow. My strategy since January has been to try to address these issues as directly and transparently as I can,” said Trevor Bedford, the study’s lead.

That includes debunking unfounded theories about COVID spreading in California in the fall of 2019, or being created in a lab.

“I still believe that science plays a role in dampening speculation and getting society to a firmer, shared factual footing,” Bedford said.

Trevor Bedford, a scientist with the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center in Seattle. (Fred Hutch Photo)

The new investigation was shared Sunday as a pre-print of non peer-reviewed research, posted on medRxiv. The site, pronounced “med-archive” is a free platform that in recent months has featured up-to-the-minute research during the COVID pandemic.

The study’s researchers include scientists from the University of Washington, Seattle’s Brotman Baty Institute for Precision Medicine, and ​Howard Hughes Medical Institute in Seattle.

Bedford and his team have done similar lineage analysis for public health departments in Washington, Florida, California, Utah, Minnesota and Michigan, as well as the U.S. Centers for Disease Control and Prevention, the European Centre for Disease Prevention and Control and Public Health England.

A story in the New York Times on Sunday shared the source of the two samples as being Times reporters. One had traveled with the president and other staff on Air Force One on Sept. 26, coming in close proximity with Trump, who was not wearing a mask. On the same day, a second journalist covered the Rose Garden event as well as a news conference the next day, with exposure to unmasked officials who later tested positive.

Both journalists, who wore masks, opted to share their identities, according to the Times.

The researchers ended the study pre-print with a slightly exasperated call to action on the U.S. COVID response.

“Science has made a great many discoveries and innovations since [the 1918 influenza pandemic], with genome sequencing being a fairly recent addition to the toolkit to combat infectious disease,” they wrote. “We, as a society, have the tools to control COVID-19, they just have to be employed.”

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Since it was revealed in early October, details about President Trump's COVID-19 infection have been in short supply, including the likely source of his… ]]>